Abstract
SAR exploration of multiple regions of a tyrosine urea template led to the identification of very potent muscarinic acetylcholine receptor antagonists such as 10b with good subtype selectivity for M(3) over M(1). The structure-activity relationships (SAR) and optimization of the tyrosine urea series are described.
MeSH terms
-
Asthma / drug therapy
-
Chemistry, Pharmaceutical / methods*
-
Drug Design
-
Humans
-
Inhibitory Concentration 50
-
Models, Chemical
-
Molecular Structure
-
Muscarinic Antagonists / chemical synthesis*
-
Muscarinic Antagonists / pharmacology
-
Receptors, Muscarinic / chemistry*
-
Salts / chemistry
-
Structure-Activity Relationship
-
Tyrosine / chemistry*
-
Urea / chemistry*
Substances
-
Muscarinic Antagonists
-
Receptors, Muscarinic
-
Salts
-
Tyrosine
-
Urea